Colonic carcinoma with linitis plastica morphology: A rare and aggressive entity with diagnostic and therapeutic implication

• Author Details:   
• Sheena John Mathew ^*
• Sunetra Mandal
• Ashwini HN
• Chandrashekhar HR
• Suresh KK

Diffuse infiltrating undifferentiated carcinoma of the colon, linitis plastica type, is a rare and aggressive variant of colorectal cancer with a poor prognosis. This case report presents a 38-year-old female with a 3-month history of abdominal pain and vomiting. Imaging revealed a transverse colonic stricture, and histopathology shows a diffusely infiltrative growth pattern with high nuclear-to-cytoplasmic ratio, karyomegaly, and minimal mitosis. Immunohistochemistry (PAN CK- tumors cells are membranous and cytoplasmic positive) supports the diagnosis. Surgical resection and adjuvant therapy was given and patient was followed up. Then she succumbed after three months due to distant metastasis to brain. This case highlights the diagnostic challenges and aggressive behaviour of the tumor